Primary Progenitor Tenocytes: Cytotherapeutics and Cell-Free Derivatives

Primary progenitor tenocytes are diploid cells that may be cultured in vitro and therapeutically used for allogeneic musculoskeletal regenerative medicine. Firstly, technical aspects of cell banking, biotechnological manufacturing, extensive preclinical characterization data have confirmed FE002-Ten primary safely considered human cytotherapeutic use (e.g., tissue engineering products, standardized transplants). Parallelly, lyophilized tenocyte extracts stabilized or cell-free derivatives) were shown to optimally act as potent hyaluronan-based hydrogel functionalizing agents, useful stability enhancement against oxidative product degradation. Therefore, source) potentially diverse clinical presentations tendon-related pathologies, ranging from volumetric replacement (i.e., the promotion enhanced graft bio-integration) local management tissular inflammation pain ancillary action cellular functional injectable preparations). Overall, investigated under Swiss transplantation program represent highly materials with a versatility potential therapeutic uses after formulation into an array preparations devices.